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EFFECT OF CHRONIC ASPIRIN ADMINISTRATION ON AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME
Author(s) -
Renicolás F,
Vazquez Marcela A,
Lama Maria C,
González Elsa S,
Miatello Roberto M
Publication year - 2009
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2008.05042.x
Subject(s) - aspirin , medicine , metabolic syndrome , oxidative stress , thiobarbituric acid , endocrinology , blood pressure , cardiology , diabetes mellitus , lipid peroxidation
SUMMARY1 The aim of the present study was to examine the effect of chronic administration of aspirin on metabolic and cardiovascular parameters in fructose‐fed rats (FFR), an experimental model of metabolic syndrome. 2 Chronic treatment of FFR with aspirin (10 mg/kg per day for 6 weeks) partially reversed the increment in systolic blood pressure. In addition, chronic aspirin treatment normalized relative heart weight and vascular remodelling of renal and carotid arteries, measured as lumen diameter : medial thickness ratio. 3 Furthermore, chronic aspirin administration completely reversed glucose intolerance and decreased the oxidative status that characterizes the FFR model, as indicated by decreased plasma levels of thiobarbituric acid‐reactive substances and aortic NAD(P)H oxidase activity. 4 Prevention of oxidative stress and vascular remodelling in FFR may contribute to the protective actions attributed to aspirin in the treatment of metabolic syndrome.