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ANTIPROLIFERATIVE ACTIVITY OF AUCUBIN IS THROUGH CELL CYCLE ARREST AND APOPTOSIS IN HUMAN NON‐SMALL CELL LUNG CANCER A549 CELLS
Author(s) -
Hung JenYu,
Yang ChihJen,
Tsai YingMing,
Huang HurngWern,
Huang MingShyan
Publication year - 2008
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2008.04935.x
Subject(s) - aucubin , apoptosis , fas ligand , a549 cell , cell cycle checkpoint , chemistry , cell cycle , cell , cancer research , biology , biochemistry , iridoid , programmed cell death , glycoside , stereochemistry
SUMMARY1 Aucubin, an iridoid glycoside isolated from the leaves of Aucuba japonica , inhibits human non‐small cell lung cancer A549 cells by blocking cell cycle progression in the G 0 /G 1 phase and inducing apoptosis. 2 An ELISA showed that the G 0 /G 1 phase arrest is due to p53‐mediated induction of p21. Enhancement of Fas and its two ligands, membrane‐bound and soluble Fas ligand, may be responsible for the apoptotic effect induced by aucubin. 3 The present study shows, for the first time, that the induction of p53 and activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of aucubin in A549 cells.