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PROMOTING PHYSIOLOGICAL HYPERTROPHY IN THE FAILING HEART
Author(s) -
Pretorius Lynette,
Owen Kate L,
Jennings Garry L,
McMullen Julie R
Publication year - 2008
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2008.04893.x
Subject(s) - muscle hypertrophy , heart failure , cardiac hypertrophy , medicine , regulator , cardiology , regeneration (biology) , stem cell , endocrinology , biology , microbiology and biotechnology , biochemistry , gene
SUMMARY1 Heart failure rates have reached epidemic proportions in Western society. 2 New strategies proposed to improve cardiac function of the failing heart include regeneration, stem cell therapy, innovative methods for the revascularization of ischaemic cardiac tissue and the activation of signalling pathways that promote physiological growth (hypertrophy). 3 The insulin‐like growth factor 1‐phosphoinositide–3‐kinase pathway is a well characterized regulator of physiological hypertrophy. 4 In this mini‐review we present studies that suggest promoting physiological hypertrophy in the failing heart may be beneficial.