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ROLE OF INSULIN‐LIKE GROWTH FACTOR 1 AND PHOSPHOINOSITIDE 3‐KINASE IN A SETTING OF HEART DISEASE
Author(s) -
McMullen Julie R
Publication year - 2008
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04873.x
Subject(s) - insulin like growth factor , regulator , growth factor , phosphoinositide 3 kinase , pi3k/akt/mtor pathway , heart disease , disease , endocrinology , function (biology) , medicine , microbiology and biotechnology , signal transduction , biology , receptor , genetics , gene
SUMMARY1 The insulin‐like growth factor 1 (IGF1)–phosphoinositide 3‐kinase (PI3‐K) pathway is a critical regulator of cell and organ growth. 2 In the heart, the IGF1–PI3‐K pathway induces physiological heart growth with preserved or enhanced cardiac function. 3 The present review specifically discusses the role of the IGF1–PI3‐K pathway in the setting of heart disease. 4 Genetic mouse models have highlighted the beneficial effects of the IGF1–PI3‐K pathway in the heart in a setting of disease. These include maintenance of contractile function, antifibrotic and anti‐apoptotic actions, inhibition of signalling transducers activated in disease settings and regeneration.