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EFFECTS OF THE CALCIUM CHANNEL BLOCKER BENIDIPINE ON MEMBRANE FLUIDITY OF ERYTHROCYTES IN SUBJECTS WITH ESSENTIAL HYPERTENSION: AN ELECTRON PARAMAGNETIC RESONANCE STUDY
Author(s) -
Tsuda Kazushi
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04783.x
Subject(s) - membrane fluidity , calcium channel blocker , medicine , essential hypertension , electron paramagnetic resonance , microcirculation , red blood cell , endocrinology , channel blocker , membrane , chemistry , calcium , blood pressure , nuclear magnetic resonance , biochemistry , physics
SUMMARY1 In the present study, the effects of benidipine, a long‐acting Ca channel blocker, on the membrane fluidity of erythrocytes in subjects with essential hypertension were examined using an electron paramagnetic resonance (EPR) and spin‐labelling method. 2 Erythrocyte membrane fluidity was significantly lower in hypertensive than normotensive subjects. 3 Benidipine increased the membrane fluidity of erythrocytes from both hypertensive and normotensive subjects in a dose‐dependent manner. The effect of benidipine was more pronounced in hypertensive subjects than in normotensive subjects. 4 The results of the present study suggest that benidipine may have a beneficial effect on the rheological behaviour and the improvement of the microcirculation in hypertension.