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CORDYCEPIN AND CORDYCEPS SINENSIS REDUCE THE GROWTH OF HUMAN PROMYELOCYTIC LEUKAEMIA CELLS THROUGH THE Wnt SIGNALLING PATHWAY
Author(s) -
Yoshikawa Noriko,
Nakamura Kazuki,
Yamaguchi Yu,
Kagota Satomi,
Shinozuka Kazumasa,
Kunitomo Masaru
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04781.x
Subject(s) - cordycepin , cordyceps , adenosine , pharmacology , receptor , wnt signaling pathway , biology , chemistry , microbiology and biotechnology , signal transduction , biochemistry , botany
SUMMARY1 The mechanism of the antitumour effect of cordycepin (3¢‐deoxyadenosine) and water extracts of Cordyceps sinensis (WECS) was examined using human promyelocytic leukaemia (HL60) cells. 2 The growth of HL60 cells was inhibited by cordycepin (60 mmol/L) and WECS (30 mg/mL) and the inhibitory effects of these agents were significantly antagonized by MRS1191, a selective adenosine A 3 receptor antagonist. 3 The growth inhibitory effects of cordycepin and WECS on HL60 cells were also significantly antagonized by indirubin, a glycogen synthase kinase (GSK)‐3b inhibitor. 4 These findings suggest that cordycepin and WECS display an antitumour effect by stimulating adenosine A 3 receptors, followed by activation of GSK‐3b in the Wnt signalling pathway.