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EFFECTS OF DIETARY FIBRE ON SHR/NDmcr‐cp ( fa k / fa k ) RAT, A MODEL OF METABOLIC SYNDROME
Author(s) -
Yasui Naomi,
HiraokaYamamoto Junko,
Kitamori Kazuya,
Nara Yasuo,
Kagawa Masaru,
Kobayakawa Akira,
Okuda Takahiro,
Ikami Takao,
Yamori Yukio,
Ikeda Katsumi
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04773.x
Subject(s) - metabolic syndrome , medicine , endocrinology , obesity , leptin , chemistry
SUMMARY1 SHR/NDmcr‐cp ( fa k /fa k ) (CP) rats have a genetic background from spontaneously hypertensive rats and carry a non‐sense mutation of the leptin receptor derived from obese Koletsky rats. CP rats show several metabolic disorders similar to patients with metabolic syndrome. The aim of the present study was to examine whether the intake of a fibre‐supplemented diet prevented the abnormalities in this metabolic syndrome rat model. 2 Male CP rats aged 6 weeks were divided into three groups and fed ad libitum a normal diet (control), a 10% soluble–insoluble fibre mixture diet (MF) and a 10% soluble fibre diet, indigestible dextrin (SF). At 23 weeks of age, abdominal obesity was attenuated in the MF group. Bodyweight gain was significantly reduced in the MF group from 16 weeks of age compared with the control group. 3 Our study suggests that a soluble–insoluble fibre mixture diet may be more effective in the primary prevention of metabolic syndrome than an insoluble diet only.