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EFFECT OF AMLODIPINE, A CALCIUM CHANNEL ANTAGONIST, ON CHOLESTEROL LEVELS IN THE CEREBRAL CORTEX AND HIPPOCAMPUS OF OBESE AND HYPERTENSIVE SHR.Cg‐ Lepr cp /NDmcr RATS
Author(s) -
Hashimoto Michio,
Kagota Satomi,
Kubota Yoko,
Katakura Masanori,
Enkhjargal Budbazar,
Gamoh Shuji,
Abdul Haque Md,
Shido Osamu,
Kunitomo Masaru,
Shinozuka Kazumasa
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04770.x
Subject(s) - amlodipine , endocrinology , medicine , hippocampus , blood pressure , cholesterol , hyperlipidemia , antagonist , chemistry , diabetes mellitus , receptor
SUMMARY1 It has been suggested that hypertension, hyperlipidemia and diabetes participate in the onset and development of dementia. We estimated the effect of the antihypertensive drug amlodipine, a calcium channel antagonist, on blood pressure, plasma lipids and cholesterol levels in the detergent insoluble membrane fractions (DIFs) of the cerebral cortex and hippocampus in obese and hypertensive SHR.Cg‐ Lepr cp /NDmcr (SHR‐cp) rats. 2 Twelve male SHR‐cp rats (10 weeks old) were randomly divided into two groups: a vehicle group and an amlodipine group administered amlodipine (8 mg/kg per day) orally for 9 weeks. 3 Bodyweight did not differ between the two groups, but the level of systolic blood pressure in the amlodipine‐administered SHR‐cp rats was significantly lower than in the vehicle rats. 4 The cholesterol levels of plasma and the DIFs in the cerebral cortex and hippocampus were both significantly higher in the amlodipine‐administered SHR‐cp rats than in the vehicle rats. Regression analysis revealed a significant positive correlation between plasma cholesterol and the cholesterol level in the DIFs of the hippocampus. 5 These results suggest that the long‐term administration of amlodipine may induce antihypertensive and hypercholesterolemic effects in obese and hypertensive SHR‐cp rats.