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INCREASED SYSTEMIC OXIDATIVE AND NITRATIVE STRESS IN A NEW CONGENIC MODEL OF METABOLIC SYNDROME DERIVED FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS AND ZUCKER FATTY RATS
Author(s) -
Yamaguchi Yu,
Yoshikawa Noriko,
Nagae Mariko,
Kagota Satomi,
Haginaka Jun,
Nakamura Kazuki,
Kunitomo Masaru
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04766.x
Subject(s) - tbars , endocrinology , medicine , oxidative stress , nitrotyrosine , metabolic syndrome , spontaneously hypertensive rat , thiobarbituric acid , chemistry , lipid peroxidation , blood pressure , obesity , nitric oxide , nitric oxide synthase
SUMMARY1 Oxidative stress has been recognized as an important factor in the biology of lifestyle‐related diseases. Systemic oxidative stress may increase in metabolic syndrome characterized by a cluster of metabolic risk factors. To confirm this hypothesis, we investigated systemic oxidative/nitrative stress in a new congenic model of metabolic syndrome, namely SHRSP/ZF rats, which are derived from stroke‐prone spontaneously hypertensive (SHRSP) and Zucker fatty (Zucker) rats. 2 The SHRSP/ZF rats display obesity, hypertension, hyperlipidaemia, hyperglycaemia and glucose intolerance. At 6 weeks of age, SHRSP/ZF rats already showed increases in serum levels of thiobarbituric acid‐reactive substances (TBARS) and oxidatively modified low‐density lipoprotein (Ox‐LDL) compared with lean SHRSP littermates and Zucker rats, whereas serum levels of 8‐hydroxy‐2′‐deoxyguanine (8‐OHdG), 3‐nitrotyrosine, 3‐chlorotyrosine and high‐sensitivity C‐reactive protein (hsCRP), an inflammatory marker, did not differ significantly among the three rat strains. However, levels of these oxidative/nirative stress markers in SHRSP/ZF rats, as well as in SHRSP, increased gradually with age. After 36 weeks of age, the levels of TBARS, 8‐OHdG, 3‐nitrotyrosine and hsCRP in SHRSP/ZF rats increased rapidly and three of six rats died thereafter. Increased oxidative/nitrative stress may be associated with death in these rats. 3 Our findings indicate that systemic oxidative/nitrative stress is evidently increased in metabolic syndrome.