EXPRESSION LEVEL OF STEROL REGULATORY ELEMENT‐BINDING PROTEINS IN A NOVEL RAT MODEL OF METABOLIC SYNDROME | Zendy

KudoOsawa Makiko | Zendy; Matsuyama Mikiko | Zendy; Noshiro Mitsuhide | Zendy; Aoyama Yuri | Zendy; Yoshida Yuzo | Zendy

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EXPRESSION LEVEL OF STEROL REGULATORY ELEMENT‐BINDING PROTEINS IN A NOVEL RAT MODEL OF METABOLIC SYNDROME

Author(s) -

KudoOsawa Makiko,

Matsuyama Mikiko,

Noshiro Mitsuhide,

Aoyama Yuri,

Yoshida Yuzo

Publication year - 2007

Publication title -

clinical and experimental pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.752

H-Index - 103

eISSN - 1440-1681

pISSN - 0305-1870

DOI - 10.1111/j.1440-1681.2007.04763.x

Subject(s) - sterol regulatory element binding protein , endocrinology , medicine , sterol , cholesterol , metabolic syndrome , chemistry , biology , diabetes mellitus

SUMMARY1 In the present study, the expression of sterol regulatory element‐binding proteins (SREBPs) in livers of a novel rat model of metabolic syndrome, namely SHRSP.Z‐ Lepr fa /IzmDmcr (SHRSP.ZF), as well as its lean littermates (SHRSP.lean), was examined. 2 The expression of SREBP‐1c was significantly elevated in SHRSP.ZF rats, whereas expression of SREBP‐2 was significantly decreased. 3 Serum cholesterol levels in SHRSP.ZF rats were significantly higher than those in SHRSP.lean rats. 4 Elevation of cholesterol levels by cholesterol loading significantly elevated SREBP‐1c levels and significantly decreased SREBP‐2 levels in SHRSP.lean rats, suggesting that serum cholesterol levels may be closely related to the expression SREBPs. 5 These results suggest that the expression of SREBP‐1c and ‐2 is modified in the metabolic syndrome rats as a result of the high cholesterol level in these rats.

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