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SYSTEMIC PLASMA LEVELS OF NITRITE/NITRATE (NO X ) REFLECT BRACHIAL FLOW‐MEDIATED DILATION RESPONSES IN YOUNG MEN AND WOMEN
Author(s) -
Casey Darren P,
Beck Darren T,
Braith Randy W
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04715.x
Subject(s) - brachial artery , medicine , nitrite , cardiology , forearm , peripheral , endothelium , nitrate , blood pressure , surgery , chemistry , organic chemistry
SUMMARY1 The aim of the present study was to determine the relationship between plasma levels of nitrite/nitrite (NO x ) and brachial flow‐mediated dilation (FMD) in healthy young men and women. 2 Brachial artery FMD was assessed non‐invasively using high‐resolution ultrasound in 36 young men and women (21 ± 3 years; 18 men and 18 women). Blood samples for NO x assays were collected from an indwelling venous catheter in the forearm following an overnight fast and a 36 h low‐nitrate diet. 3 Plasma levels of NO x were related to peak brachial FMD% ( r = 0.53; P = 0.001). The relationship was maintained when the brachial dilation was expressed as absolute diameter change (Δmm; r = 0.51; P = 0.002) and when it was normalized (/s) to the mean shear rate ( r = 0.50; P = 0.002). 4 The present study demonstrates a relationship between peak FMD in the brachial artery and plasma levels of NO x in young men and women. This relationship suggests that brachial FMD and/or plasma NO x may be used as markers of peripheral endothelial function.