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SENSORY NEURAL TARGETS FOR THE TREATMENT OF COUGH
Author(s) -
Mazzone Stuart B,
McGovern Alice E
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04702.x
Subject(s) - cough reflex , reflex , medicine , sensory system , chronic cough , neuroscience , anesthesia , airway , intensive care medicine , asthma , psychology
SUMMARY1 Cough is a primary defensive reflex that protects the airways from potentially harmful stimuli. 2 During many respiratory diseases, the cough reflex threshold is lowered and coughing becomes excessive. 3 Currently available therapeutics are mostly ineffective at suppressing excessive coughing. 4 In the present review, we describe the sensory neural pathways involved in cough, how these pathways may become dysfunctional in airway disease and the most recent advances that have been made in identifying future targets for cough suppression.