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DECREASED THRESHOLD FOR THE NITRIC OXIDE DONOR GLYCERYL TRINITRATE IN CORTISOL‐INDUCED HYPERTENSION IN HUMANS
Author(s) -
Kelly JJ,
Tam SH,
Williamson PM,
Whitworth JA
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04700.x
Subject(s) - nitric oxide , medicine , pharmacology , nitroglycerin (drug) , endocrinology , chemistry , anesthesia
SUMMARY1 Decreased nitric oxide (NO) availability is thought to be a feature of cortisol‐induced hypertension in humans. 2 We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3 We re‐analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4 Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5 These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.