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SPINAL α‐AMINO‐3‐HYDROXY‐5‐METHYL‐4‐ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Author(s) -
Hang LiHua,
Shao DongHua,
Yang YingHong,
Dai TiJun,
Zeng YinMing
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04690.x
Subject(s) - ampa receptor , analgesic , chemistry , sevoflurane , isoflurane , pharmacology , enflurane , anesthesia , spinal cord , threshold of pain , intrathecal , glutamate receptor , receptor , medicine , biochemistry , psychiatry
SUMMARY1 The present study was designed to investigate the relationship between spinal cord α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors and the analgesic effects of emulsified halogenated anaesthetics. 2 After having established the mouse model of analgesia by intraperitoneal or subcutaneous injections of appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we injected different doses of AMPA intrathecally and observed effects on the pain threshold using the hot‐plate and acetic acid‐induced writhing tests. 3 The results showed that intrathecal injection of AMPA (0.25, 0.5 and 1.0 ng) did not affect the pain threshold on the hot‐plate test or the writhing times in conscious mice. In contrast, AMPA (0.25, 0.5 and 1.0 ng intrathecally) significantly and dose‐dependently decreased the pain threshold on the hot‐plate test and increased the writhing times in mice treated with emulsified anaesthetics. 4 These results suggest that spinal AMPA receptors may be important targets for the analgesic effects of emulsified enflurane, isoflurane and sevoflurane.