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ROLE OF REACTIVE METABOLITES OF OXYGEN AND NITROGEN IN PARTIAL LIVER TRANSPLANTATION: LESSONS LEARNED FROM REDUCED‐SIZE LIVER ISCHAEMIA AND REPERFUSION INJURY
Author(s) -
Urakami Hidejiro,
Abe Yuta,
Grisham Matthew B
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04640.x
Subject(s) - liver transplantation , transplantation , ischemia , reperfusion injury , medicine , pathophysiology , surgery , bioinformatics , intensive care medicine , pathology , biology
SUMMARY1 Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced‐size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant number of patients develop tissue injury from these procedures, ultimately resulting in graft failure. 2 Because of this, there is a real need to understand the different mechanisms responsible for the tissue injury induced by I/R of RSL transplantation (RSL + I/R), with the ultimate goal to develop new and improved therapeutic agents that may limit the tissue damage incurred during RSL transplantation. 3 The present paper reviews the recent studies that have been performed examining the role of reactive metabolites of oxygen and nitrogen in a mouse model of RSL + I/R. In addition, we present data demonstrating how the pathophysiological mechanisms identified in this model compare with those observed in a model of RSL transplantation in rats.