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N ITRIC O XIDE, E RECTILE D YSFUNCTION AND BETA‐BLOCKER TREATMENT (MR NOED STUDY): BENEFIT OF NEBIVOLOL VERSUS METOPROLOL IN HYPERTENSIVE MEN
Author(s) -
Brixius K,
Middeke M,
Lichtenthal A,
Jahn E,
Schwinger R H G
Publication year - 2007
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2007.04551.x
Subject(s) - nebivolol , metoprolol , medicine , erectile dysfunction , blood pressure , placebo , cardiology , beta blocker , sexual dysfunction , essential hypertension , anesthesia , heart failure , alternative medicine , pathology
SUMMARY1 Hypertensive men treated with beta‐blockers frequently complain of erectile dysfunction. The present study investigated the effects of two β 1 ‐adrenoceptor‐selective antagonists, namely nebivolol and metoprolol, on erectile function in hypertensive men. 2 Male out‐patients (age range 40–55 years) with newly diagnosed or existing stage 1 essential hypertension (mean seated systolic blood pressure 140–159 mmHg; diastolic blood pressure 90–99 mmHg) were enrolled in the study. All patients lived in a stable, heterosexual partnership and had no history of sexual dysfunction. After a 2 eek placebo run‐in period, patients were randomized double‐blind to either Treatment group A (comprising nebivolol 5 mg once daily for 12 weeks, followed by placebo for 2 weeks and then metoprolol succinate 95 mg once daily for 12 weeks) or Treatment group B (comprising metoprolol succinate 95 mg for 12 weeks, placebo for 2 weeks and then nebivolol 5 mg for 12 weeks). An international index of erectile function (IIEF) questionnaire and a diary documented patients’ sexual function and activity. 3 Nebivolol and metoprolol lowered blood pressure to a similar extent. Metoprolol, but not nebivolol, significantly decreased the IIEF erectile function subscore by 0.92 in the first 8 weeks after onset of beta‐blocker treatment. In contrast with metoprolol, nebivolol improved secondary sexual activity scores and other IIEF subscores. 4 Despite similar antihypertensive efficacy of the cardioselective β 1 ‐adrenoceptor antagonists nebivolol and metoprolol, nebivolol may offer additional benefits by avoiding erectile dysfunction in male hypertensive patients on long‐term β‐adrenoceptor antagonist therapy.