Premium
PROTECTIVE EFFECTS OF BENDAZAC LYSINE ON DIABETIC PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN‐INDUCED DIABETIC RATS
Author(s) -
Yu JunXian,
Zhang YinDi,
Yin XiaoXing,
Shen JianPing,
Qiu Jun,
Yin HongLin,
Jiang ShaoJun
Publication year - 2006
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2006.04515.x
Subject(s) - polydipsia , medicine , endocrinology , diabetes mellitus , streptozotocin , peripheral neuropathy , diabetic neuropathy , polyuria , glycation , insulin
SUMMARY1 Diabetic neuropathy is a many faceted complication of both type I and II diabetes. The aim of the present study was to investigate the effects of bendazac lysine (BDL), an anticataract drug, on experimental diabetic peripheral neuropathy (DPN) in rats. 2 Diabetes was induced in rats by intraperitoneal injection of 75 mg/kg streptozotocin (STZ) dissolved in 0.1 mol/L citrate buffer (pH 4.4). Bendazac lysine was administered to rats at doses of 50, 100 and 200 mg/kg twice a day for 12 weeks. 3 Diabetic rats without treatment showed hypopraxia, polydipsia, polyuria, slow weight gain, cataract, increased tail‐flick threshold temperature, decreased motor nerve conduction velocity (nd induced pathological morphological changes of myelinated nerve fibres. All these symptoms were ameliorated in diabetic rats treated with BDL. Bendazac lysine ameliorated the blood glucose concentration, glycosylated haemoglobin levels and insulin levels in the plasma of diabetic rats, reduced aldose reductase activity in erythrocytes and advanced glycation end‐products in both nerves and serum and increase the activity of glutathione peroxidase in the nerves and Na + /K + ‐ATPase in the nerves and erythrocytes. 4 Bendazac lysine exerts its protective effects against the progression of diabetic peripheral neuropathy in STZ‐diabetic rats through multiple mechanisms and is a potential drug for the prevention of deterioration in DPN.