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SPECIES VARIABILITY IN CARDIOVASCULAR RESEARCH: THE EXAMPLE OF ADRENOCORTICOTROPHIN‐INDUCED HYPERTENSION
Author(s) -
Whitworth Judith A,
Zhang Yi,
Mangos George,
Kelly John J
Publication year - 2006
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2006.04460.x
Subject(s) - animal study , animal studies , human studies , medicine , animal model , endocrinology , physiology , biology , surgery
SUMMARY1 Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2 Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3 A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4 Caution should be exercised in extrapolating data from animals to humans.