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THERAPEUTIC VACCINATION FOR CENTRAL NERVOUS SYSTEM REPAIR
Author(s) -
Ang Beng Ti,
Xu Gang,
Xiao Zhi Cheng
Publication year - 2006
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2006.04404.x
Subject(s) - central nervous system , vaccination , neuroscience , medicine , remyelination , traumatic brain injury , myelin , immune system , regeneration (biology) , oligodendrocyte , neurite , immunology , stroke (engine) , multiple sclerosis , biology , mechanical engineering , biochemistry , psychiatry , engineering , in vitro , microbiology and biotechnology
SUMMARY1 Vaccination against infectious agents has been heralded as a triumph in modern medicine and, more recently, cancer vaccines have risen in prominence. The present review looks towards the use of vaccine therapy to attenuate damage after injury to the central nervous system (CNS). 2 Significant debility is associated with brain injury, most commonly occurring as a result of physical trauma or stroke. This end result reflects the inability of neurons and axons to regenerate following injury to the CNS. This unconducive environment is due, in large part, to the presence of myelin and oligodendrocyte‐related inhibitors of neurite outgrowth. 3 We review how a vaccine‐based approach has been variably used to circumvent this issue and promote axonal regeneration and repair following traumatic injury and other neurodegenerative disorders. In addition, emerging evidence suggests that the immune response to injury in the CNS may be manipulated so as to reduce cellular damage. Vaccine‐directed approaches using this concept are also outlined.