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CD4 + CD25 + REGULATORY T CELLS IN HEALTH AND DISEASE
Author(s) -
Liu Haiying,
Leung Bernard P
Publication year - 2006
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2006.04401.x
Subject(s) - il 2 receptor , immunology , autoimmunity , regulatory t cell , biology , effector , microbiology and biotechnology , medicine , t cell , immune system
SUMMARY1 Over the past 5 years, tremendous progress has been made in understanding the suppressive mechanisms of T regulatory (Treg) cells. The Treg cells, a subpopulation of T cells, have been shown to play an important role in maintaining peripheral tolerance and the prevention of autoimmunity. 2 Various populations of Treg cells have been described, including thymically derived CD4 + CD25 + Treg cells. These naturally occurring Treg cells are present in the periphery and are capable of suppressing proliferation and effector T cell responses both in vitro and in vivo . 3 In addition, a second subset of Treg cells, type 1 T regulatoary (Tr1) and Th3 cells, exert their suppressive capacity via cytokines such as interleukin‐10 and transforming growth factor‐b and are contact independent. 4 The present review summarizes the characteristics and molecular basis of CD4 + CD25 + Treg cells, as well as their therapeutic potential in modulating inflammatory diseases, such as inflammatory bowel disease and rheumatoid arthritis.