Premium
DNA MICROARRAY TECHNOLOGY FOR TARGET IDENTIFICATION AND VALIDATION
Author(s) -
Jayapal Manikandan,
Melendez Alirio J
Publication year - 2006
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2006.04398.x
Subject(s) - dna microarray , identification (biology) , microarray , gene chip analysis , computational biology , microarray analysis techniques , drug development , disease , mechanism (biology) , bioinformatics , data science , biology , computer science , gene , drug , medicine , genetics , gene expression , pharmacology , pathology , philosophy , botany , epistemology
SUMMARY1 Microarrays, a recent development, provide a revolutionary platform to analyse thousands of genes at once. They have enormous potential in the study of biological processes in health and disease and, perhaps, microarrays have become crucial tools in diagnostic applications and drug discovery. 2 Microarray based studies have provided the essential impetus for biomedical experiments, such as identification of disease‐causing genes in malignancies and regulatory genes in the cell cycle mechanism. Microarrays can identify genes for new and unique potential drug targets, predict drug responsiveness for individual patients and, finally, initiate gene therapy and prevention strategies. 3 The present article reviews the principles and technological concerns, as well as the steps involved in obtaining and analysing of data. Furthermore, applications of microarray based experiments in drug target identifications and validation strategies are discussed. 4 To exemplify how this tool can be useful, in the present review we provide an overview of some of the past and potential future aspects of microarray technology and present a broad overview of this rapidly growing field.