Premium
ANTIDIABETIC EFFECT OF A NEW PEPTIDE FROM SQUALUS MITSUKURII LIVER (S‐8300) IN ALLOXAN‐DIABETES
Author(s) -
Huang Fengjie,
Wu Wutong
Publication year - 2005
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2005.04224.x
Subject(s) - alloxan , malondialdehyde , endocrinology , medicine , triglyceride , chemistry , diabetes mellitus , insulin , superoxide dismutase , cholesterol , oxidative stress
SUMMARY 1. The purpose of the present study was to evaluate the antidiabetic effect of S‐8300 in alloxan diabetic mice. 2. Diabetes was induced by single intravenous injection of alloxan (60 mg/kg bodyweight). 3. The effects of S‐8300 on diabetic mice were investigated by observing changes in the glycometabolic index (fasting plasma glucose, glycosylated haemoglobin), the lipometabolic index (triglyceride, cholesterol, free fatty acids), anti‐oxidant index (superoxide dismutase, malondialdehyde) and in the degree of injury of β‐cells in the pancreatic islets. 4. A significant decrease in fasting plasma glucose, glycosylated haemoglobin, triglycerides, cholesterol, free fatty acids in the plasma and malondialdehyde in the tissues, as well as a significant increase in the activity of superoxide dismutase, was observed in diabetic mice treated with 10, 3 and 1 mg/kg S‐8300. 5. Treatment with S‐8300 also attenuated the degree of injury of β‐cells. 6. A comparison was made between the action of S‐8300 and 6 U/kg insulin. The effects of S‐8300 were similar to those of insulin.