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BRAIN PHARMACOKINETICS OF LIGNOCAINE BEFORE and FOLLOWING INTRAVENOUS PERFLUOROCARBON EMULSION INFUSION IN SHEEP
Author(s) -
Doolette David J,
Upton Richard N,
Martinez Allison M
Publication year - 2005
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2005.04197.x
Subject(s) - pharmacokinetics , anesthesia , medicine , emulsion , blood substitute , pharmacology , chemistry , hemoglobin , biochemistry
SUMMARY 1. Perfluorocarbon emulsions have potential medical applications, particularly as temporary oxygen carriers and are likely to be coadministered with other intravenous drugs. It is possible that perfluorocarbon emulsions may alter the disposition of other drugs in the body. 2. In the present study, we examined the brain pharmacokinetics of a 5 min infusion of 100 mg lignocaine in three chronically instrumented sheep before and after the administration of a new investigational perflurocarbon emulsion (Oxygent™; Alliance Pharmaceutical, San Diego, CA, USA). 3. The rate constant for the blood : brain equilibration of lignocaine was larger after perflubron administration. This change could not be attributed to a change in brain blood flow and, therefore, may be the result of a change in the free fraction of lignocaine in the blood.