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EUPHORBIA THYMIFOLIA SUPPRESSES HERPES SIMPLEX VIRUS‐2 INFECTION BY DIRECTLY INACTIVATING VIRUS INFECTIVITY
Author(s) -
Yang ChienMin,
Cheng HuaYew,
Lin TaChen,
Chiang LienChai,
Lin ChunChing
Publication year - 2005
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2005.04194.x
Subject(s) - infectivity , herpes simplex virus , virology , virus , biology
SUMMARY 1. The ethyl acetate (EtOAc) extract and 3‐ O ‐galloyl‐4,6‐( S )‐hexahydroxydiphenoyl‐ d ‐glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti‐herpes simplex virus (HSV)‐2 activity in vitro . In the present study, we investigated the mode of action of these two compounds in suppressing HSV‐2 multiplication. 2. The results demonstrated that the EtOAc extract and 3OG46HG affected virus infectivity in a dose‐dependent manner. The EtOAc extract significantly reduced virus infectivity at a concentration of 4.0 µg/mL, whereas 3OG46HG obviously diminished virus infectivity at concentration of a 0.5 µg/mL. The virucidal ability of the EtOAc extract was affected by the incubation period, but not by the incubation temperature. In the case of the action of 3OG46HG against HSV‐2, the effects of incubation time and temperature were negligible. 3. In summary, the EtOAc extract and 3OG46HG of E. thymifolia are concluded to inhibit HSV‐2 multiplication by reducing virus infectivity.