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FISH and LIFESTYLE‐RELATED DISEASE PREVENTION: EXPERIMENTAL AND EPIDEMIOLOGICAL EVIDENCE FOR ANTI‐ATHEROGENIC POTENTIAL OF TAURINE
Author(s) -
Yamori Yukio,
Murakami Shigeru,
Ikeda Katsumi,
Nara Yasuo
Publication year - 2004
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2004.04122.x
Subject(s) - taurine , medicine , endocrinology , excretion , oxidative stress , cholesterol , blood pressure , chemistry , amino acid , biochemistry
Summary 1. Taurine supplementation attenuated the development of hypertension and stroke in stroke‐prone spontaneously hypertensive rats (SHRSP). 2. WHO‐CARDIAC (Cardiovascular Diseases Alimentary Comparison) study revealed wide differences in 24‐h urinary taurine excretion, which were inversely associated with age‐adjusted mortality rates of coronary heart diseases (CHD). 3. Hypercholesterolemia as well as arterial fat deposition related to the cause of CHD was attenuated by dietary taurine supplementation in SHRSP on high‐fat cholesterol diet. 4. Taurine affected the gene expression of 7α‐hydroxylase and thus regulated serum cholesterol level through the control of the rate limiting step of cholesterol excretion into bile acids. 5. Taurine attenuated atherogenesis due to the control of oxidative stress through the inhibition of the production of oxidative LDL and to its scavenger effect on hypochlorous acid (HOCl) from leucocytes and macrophages. 6. Taurine may act as an immunomodulator of cytokine production, which is involved in atherogenesis.