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ASSOCIATION OF LUNG FUNCTION WITH ATHEROSCLEROTIC RISK FACTORS AMONG JAPANESE AMERICANS: SEATTLE NIKKEI HEALTH STUDY
Author(s) -
Taneda Kenichiro,
Namekata Tsukasa,
Hughes Deborah,
Suzuki Kenji,
Knopp Robert,
Ozasa Kotaro
Publication year - 2004
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2004.04116.x
Subject(s) - medicine , vital capacity , pulse wave velocity , lung function , blood pressure , risk factor , cardiology , logistic regression , lung , pulmonary function testing , diffusing capacity
SUMMARY 1. Impaired lung function has been reported to be associated with mortality from all causes, cardiovascular disease (CVD) and aortic pulse wave velocity (PWV). The aim of the present study was to examine the association between impaired lung function and atherosclerotic risk factors, including PWV, blood pressure, lipids, smoking and alcohol intake, among Japanese Americans. 2. The study subjects were 678 adult Japanese Americans who participated in CVD screening conducted under the Seattle Nikkei Health Study. Subjects with abnormal lung function were defined as those with forced vital capacity (FVC%) < 80% of predicted or forced expiratory volume in 1 s (FEV 1 %) < 80% of predicted. We conducted logistic regression analyses by using abnormal lung function as dependent variables. 3. The significant predictors positively associated with abnormal FVC% were age (60 years or older) and hypertension. Being a current drinker or an ex‐drinker was independently and negatively associated with abnormal FVC%. The significant predictors positively associated with abnormal FEV 1 % were age (60 years or older), sex (male), hypertension and being a current smoker. Being a current drinker was independently and negatively associated with abnormal FEV 1 %. 4. In conclusion, the present study does not support the previously reported association of abnormal lung function with PWV. However, our findings imply that light and moderate drinking may be a protective factor of lung function and that hypertension and smoking may impair lung function.