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GABA C RECEPTOR ION CHANNELS
Author(s) -
Chebib M
Publication year - 2004
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2004.04083.x
Subject(s) - receptor , gabaa rho receptor , neuroscience , anxiety , ion channel , pharmacology , gabaa receptor , chemistry , biology , psychology , biochemistry , psychiatry
SUMMARY 1. The present review gives an overview of studies conducted on GABA C receptors over the past 10 years since the author started at the University of Sydney. It concentrates on the structure–activity relationship profiles of the receptor and how these studies were used to: (i) develop selective GABA C receptor ligands; and (ii) understand the impact of amino acid changes on GABA C receptor pharmacology and function. 2. Structure–activity relationship studies involving variations of both ligands and their receptor targets are vital to the discovery of drugs that interact selectively with particular native and mutant receptor subtypes. Such agents may be useful for treating anxiety, depression, epilepsyand memory related disorders, such as Alzheimer's disease.