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STRETCH‐ACTIVATED CHANNELS IN STRETCH‐INDUCED MUSCLE DAMAGE: ROLE IN MUSCULAR DYSTROPHY
Author(s) -
Yeung Ella W,
Allen David G
Publication year - 2004
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2004.04027.x
Subject(s) - muscle damage , dystrophin , chemistry , intracellular , muscular dystrophy , sarcolemma , biophysics , medicine , membrane , biology , biochemistry
SUMMARY 1. Stretch‐induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch‐activated channels and blocking these channels with Gd 3+ or streptomycin reduces the force deficit associated with damage. 2. Dystrophin‐deficient muscles are more susceptible to stretch‐induced muscle injury and the recovery from injury can be incomplete. We have found that Na + entry associated with stretch‐induced injury is enhanced in dystrophin‐deficient muscles and that blockers of stretch‐activated channels are capable of preventing ionic entry and reducing muscle damage. 3. A model is presented that proposes links between stretch‐induced injury, opening of stretch‐activated channels, increased levels of intracellular ions and various forms of muscle damage. Although changes in Na + accompany stretch‐induced muscle injury, we believe that changes in Ca 2+ probably have a more central role in the damage process.