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DOSE‐DEPENDENT EFFECT OF CAPTOPRIL ON AORTIC REACTIVITY OF STREPTOZOTOCIN‐DIABETIC RATS
Author(s) -
Baluchnejadmojarad Tourandokht,
Roghani Mehrdad,
Imani Alireza
Publication year - 2004
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2004.04006.x
Subject(s) - captopril , streptozotocin , medicine , cardiology , pharmacology , diabetes mellitus , endocrinology , blood pressure
Summary 1. Diabetes mellitus is a primary risk factor for cardiovascular disorders. Strategies that interrupt the renin–angiotensin system have been known to reduce cardiovascular disease. The present study was performed to investigate the effect of sub‐chronic administration of captopril on the aortic reactivity of streptozotocin‐diabetic rats. 2. Streptozotocin‐diabetic rats received captopril (30 and 50 mg/kg per day) for 2 months. Contractile responses to phenylephrine (PE) and relaxation responses to acetylcholine (ACh) and isosorbide dinitrate (ISD) were obtained from aortic rings. 3. Concentration–response curves from captopril‐treated diabetic rats to PE were attenuated compared with vehicle (Saline)‐treated diabetic rats, especially at a dose of 50 mg/kg captopril. In addition, endothelium‐dependent relaxation responses induced by ACh were significantly higher in captopril‐treated diabetic rats compared with diabetic rats. The endothelium‐independent relaxation responses for ISD were found not to be significantly different among the groups. 4. Therefore, sub‐chronic treatment of diabetic rats with captopril in a dose‐dependent manner could prevent the functional changes in vascular reactivity in diabetic rats.