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EFFECT OF GRAPEFRUIT JUICE ON URINARY 6β‐HYDROXYCORTISOL/CORTISOL EXCRETION
Author(s) -
Seidegård Janeric,
Dahlström Kerstin,
Kullberg Annika
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02366.x
Subject(s) - grapefruit juice , cyp3a , ingestion , endocrinology , medicine , excretion , urine , urinary system , chemistry , metabolism , hydrocortisone , pharmacokinetics , cytochrome p450
SUMMARY 1. The aim of the present study was to evaluate the effect of grapefruit juice on urinary 6β‐hydroxycortisol and Cortisol excretion in healthy subjects. 2. The ratio of 6β‐hydroxycortisol/cortisol was significantly decreased ( P = 0.036) in the 0–4 h fraction of urine after ingestion of grapefruit juice, but not in the 4–24 h fraction ( P = 0.218) or for the compiled data, fraction 0–24 h ( P = 0.114). 3. These results indicate that endogenous Cortisol metabolism may not only be of hepatic origin, but may also be dependent on the metabolic capacity of cytochrome P450IIIA (CYP3A) in the gut mucosa. 4. This finding may cast further doubts of the usefulness of the 6β‐hydroxycortisol/cortisol ratio as an indicator of hepatic CYP3A activity.