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CAPTOPRIL INHIBITS BOTH DOPAMINERGIC AND CHOLINERGIC NEUROTRANSMISSION IN THE CENTRAL NERVOUS SYSTEM
Author(s) -
Tsuda Kazushi,
Tsuda Seiko,
Nishio Ichiro,
Masuyama Yoshiaki,
Goldstein Menek
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02341.x
Subject(s) - captopril , dopamine , dopaminergic , endocrinology , acetylcholine , medicine , striatum , cholinergic , stimulation , chemistry , neurotransmitter , cholinergic neuron , central nervous system , biology , blood pressure
SUMMARY 1. The present study was performed to investigate the effects of captopril on both dopaminergic and cholinergic neurotransmission in the rat central nervous system . 2. Slices of rat striatum were prepared and prelabelled with [ 3 H]‐dopamine or [ 3 H]‐choline. Slices were continuously super‐fused with Krebs'‐Ringer solution and electrical stimulation (1 Hz) was performed . 3. Captopril significantly inhibited stimulation‐evoked [ 3 H]‐dopamine release from rat striatal slices in a concentration‐dependent manner (S2/S1 ratios: control 0.83S±0.018 ( n = 6); 1×10 −5 mol/L captopril 0.597±0.035 ( n = 6; P <0.05); 5 × 10 −5 mol/L captopril 0.561 ± 0.041 ( n = 6; P< 0.05)). However, the basal release of [ 3 H]‐dopamine was not affected by captopril . 4. Captopril also reduced stimulation‐evoked [ 3 H]‐acetyl‐choline release in the striatum (S2/S1 ratios: control 0.891 ±0.016 ( n = 6); 1 × 10 −5 mol/L captopril 0.794±0.011 ( n = 6; P <0.05)) . 5. These results show that captopril inhibits the release of both dopamine and acetylcholine in the rat striatum. Although the mechanisms underlying the neurosuppressive effects of captopril remain to be determined, the findings suggest that the inhibition of dopaminergic and cholinergic neurotransmission may be related to the central action of the angiotensin‐converting enzyme inhibitor .