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PHARMACOLOGICAL STIMULATION OF ARTERIAL CHEMORECEPTORS IN CONSCIOUS RATS PRODUCES DIFFERENTIAL RESPONSES IN RENAL CORTICAL AND MEDULLARY BLOOD FLOW
Author(s) -
Ledderhos Carla,
Gross Volkmar,
Jr Allen W Cowley
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02247.x
Subject(s) - stimulation , chemoreceptor , renal blood flow , medullary cavity , blood flow , medicine , anesthesia , neuroscience , kidney , biology , receptor
SUMMARY 1. There have been no previously published data regarding intrarenal blood flow distribution in acute whole‐body hypoxic hypoxia and/or arterial chemoreceptor stimulation in normoxic mammals. 2. Cortical and medullary blood flows were measured simultaneously before and in response to pharmacological stimulation of peripheral arterial chemoreceptors by i.v. injection of almitrine bismesylate (0.25 mg/kg). 3. Arterial chemoreceptor excitation reduced cortical blood flow but only in innervated kidneys. An effect on medullary blood flow was observed in neither innervated nor denervated kidneys. 4. These data indicate that renal cortical and medullary blood flows react differently to arterial chemoreceptor stimulation.