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CENTRAL REGULATION OF AUTONOMIC FUNCTION: NO BRAKES?
Author(s) -
Krukoff Teresa L.
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02238.x
Subject(s) - hypothalamus , endocrinology , medicine , rostral ventrolateral medulla , vasopressin , rostral ventromedial medulla , medulla oblongata , brainstem , supraoptic nucleus , biology , medulla , central nucleus of the amygdala , neuroscience , central nervous system , nociception , receptor , hyperalgesia
SUMMARY 1. Nitric oxide (NO) is formed by neuronal NO synthase (nNOS) and acts as a non‐conventional neurotransmitter in the brain. A growing body of evidence supports the hypothesis that NO acts to decrease sympathetic output to the periphery; these effects may occur at several autonomic sites. The present review describes studies from our laboratory that address this hypothesis. 2. Restraint stress activates putative NO‐producing neurons in many autonomic centres: preoptic area, medial septum, amygdala, hypothalamus, including the paraventricular nucleus (PVN), raphe nuclei, nucleus tractus solitarius (NTS) and ventrolateral medulla (VLM). These results suggest that NO is directly or indirectly involved in regulating sympathetic output to the periphery. 3. Systemic angiotensin II (Angll) activates putative NO‐producing neurons in the PVN. These neurons may be activated either by the increases in arterial pressure that accompany Angll injections or due to activation of AngII‐containing neural pathways. 4. Hypotension is associated with the activation of putative NO‐producing PVN neurons, small numbers of which also project to the NTS or VLM. As the majority of activated neurons is in the magnocellular division, NO production may be related to the production of vasopressin. 5. Adult spontaneously hypertensive rats (SHR) show increased gene expression of nNOS in the hypothalamus, dorsal medulla and caudal VLM. These differences are not present in young prehypertensive SHR, suggesting that the changes in gene expression in adult rats are associated with the increased sympathetic nerve activity found in these rats. 6. Gene expression of nNOS is altered in the hypothalamus and caudal VLM of renal hypertensive rats at 3 and 6 weeks after surgical induction of hypertension. Contrasting results at the two time points may be due to differing underlying physiological processes that characterize the two stages of renal hypertension. 7. Nitric oxide may affect sympathetic output through several possible mechanisms. These include affecting production of the second messenger cGMP and interactions with more classical neurotransmitters or with neurohormonal systems in the brain.