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EFFECTS OF FR139317 ON RENAL RESPONSES TO ACUTE NITRIC OXIDE BLOCKADE IN ANAESTHETIZED RATS
Author(s) -
Matsumura Yasuo,
Kuro Toshihiko,
Hashimoto Norio,
Taira Shima
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02229.x
Subject(s) - nitric oxide , blockade , medicine , pharmacology , anesthesia , cardiology , receptor
SUMMARY 1. Effects of FR139317, an endothelin ET A receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of N G ‐nitro‐ l ‐arginine (NOARG), the NO synthase inhibitor, at a rate of 40 μg/kg per min, produced a significant decrease in renal blood flow, with no change in systemic blood pressure. There were significant decreases in urine flow and urinary excretion of sodium during infusion of NOARG. In animals pretreated with FR139317, similar renal responses to the NOARG infusion were observed. 3. These results suggest that an action of endothelin‐1 via ET A receptors does not greatly contribute to the renal haemodynamic and excretory responses to acute blockade of renal NO production.