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ROLE OF NITRIC OXIDE IN THE DEVELOPMENT OF CORTICOTROPIN‐INDUCED HYPERTENSION IN SHEEP
Author(s) -
Tresham JJ,
May CN
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02189.x
Subject(s) - nitric oxide , medicine , endocrinology
SUMMARY 1. The possibility that altered synthesis of vascular nitric oxide (NO) plays a role in the development of corticotropin‐induced hypertension in sheep was examined by determining the effect of concomitant infusion of L‐arginine, a precursor of NO, on the development of the hypertension. 2. Corticotropin (5 μg/kg per h) infused over 2 days increased mean arterial pressure (MAP) from 83 ± 4 to 99 ± 4 mmHg in five conscious sheep. Concomitant infusion of L‐arginine (60 mg/kg per h) did not alter this response; infusion of L‐arginine alone had no effect on blood pressure. 3. The dose of L‐arginine (60 mg/kg per h) used blocked the rise in MAP (+16 mmHg) in response to a 5 h infusion of N ‐nitro‐L‐arginine (1 mg/kg per h). 4. These findings suggest that disruption of NO synthesis does not play a role in the development of corticotropin hypertension in sheep.