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EFFECTS OF QUANTITATIVE TRAIT LOCI FOR LIPID PHENOTYPES IN THE RAT ARE INFLUENCED BY AGE
Author(s) -
Kovács Peter,
Brandt Jens,
Klöting Ingrid
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.tb02174.x
Subject(s) - quantitative trait locus , backcrossing , phenotype , biology , chromosome , genetic linkage , genetics , chromosome 4 , genetic marker , chromosome 16 , endocrinology , medicine , gene
SUMMARY 1. Previous study on the backcross hybrids derived from a cross of the spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat demonstrated the existence of quantitative trait loci (QTL) affecting lipid phenotypes on chromosome 4 and suggestive linkage of lipid phenotypes with markers on chromosome 1. Because the previous study was performed with backcross hybrids at 12 weeks of age and it is known that lipid phenotypes can show age‐related differences, in the present study, the effect of QTL (chromosome 1 and 4) on serum triglycerides and cholesterol was longitudinally analysed between 20 and 32 weeks of age in backcross hybrids. 2. The results of the present study show that the effect of QTL on chromosome 4 (between Il‐6 and D4Mit 9) for serum triglycerides was maximal at 20 weeks of age, but disappeared at 32 weeks of age. In contrast, the effect of QTL on serum total cholesterol on chromosome 4 ( Npy‐Spr ) was maximal at 32 weeks of age. In contrast with the first study (12 weeks), the longitudinal investigation showed significant linkage of D1Mit14 marker with lipid phenotypes on chromosome 1. 3. The results of the present study indicate the necessity of considering the role of age in QTL analysis of lipid phenotypes.