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COSEGREGATION OF THE Tnfα LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F 2 GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS
Author(s) -
Harris Eugenie L,
Grigor Murray R,
Thompson Caryn M
Publication year - 1998
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1998.t01-17-.x
Subject(s) - locus (genetics) , allele , genotype , biology , genetics , blood pressure , gene , endocrinology , medicine , phenotype , quantitative trait locus , population , environmental health
1. The association of the Tnfα locus with several cardiovascular phenotypes and body mass has been studied in the F 2 generation of a reciprocal cross between rats of the New Zealand genetically hypertensive (GH) and the normotensive Brown Norway (BN) strains. In the total F 2 population the GH allele of Tnfα cosegregated with increased intra‐arterial blood pressure (BP) in a recessive manner. A similar but weaker effect was observed for tail BP. 2. An association between genotype and body mass in females with GH grandfathers was also detected. 3. An association between genotype and pulse rate was observed for females. 4. This work supports other evidence pointing to an association of a gene (or genes) on rat chromosome 20 with hypertension.