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ROLE OF LIPOPROTEIN‐X IN FOAM CELL FORMATION AND RAT MESANGIAL CELL PROLIFERATION
Author(s) -
Lynn Edward G.,
O Karmin
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb02731.x
Subject(s) - foam cell , mesangial cell , oil red o , cell growth , chemistry , macrophage , cholesteryl ester , lipoprotein , incubation , staining , cholesterol , cell , microbiology and biotechnology , biochemistry , biology , in vitro , pathology , medicine , adipogenesis
SUMMARY 1. In the present study, the effect of reconstituted lipoprotein‐X (rLp‐X) on lipid accumulation and foam cell formation in rat peritoneal macrophages was evaluated. Furthermore, the combined effect of rLp‐X and macrophages on mesangial cell proliferation was examined. 2. Incubation of macrophages with rLp‐X (177 and 387nmol unesterified cholesterol (FC)/mL) resulted in an increase of cellular cholestero. (162%) and cholesteryl esters (223 to 245%) relative to control. 3. Oil Red O staining of macrophages treated with rLp‐X revealed the presence of foa. cells. 4. In conclusion, rLp‐X had no effect on the proliferation of mesangial cells incubated in macrophage‐conditione. medium.