Premium
POTENTIATION OF DIPSOGENIC ACTIONS BY CENTRALLY ADMINISTERED TYPE‐C NATRIURETIC PEPTIDE IN SPONTANEOUSLY HYPERTENSIVE BUT NOT WISTAR‐KYOTO RATS
Author(s) -
Goto Eiichi,
Shibata Kazuhiko,
Furukawa Tatsuo
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb02721.x
Subject(s) - medicine , endocrinology , angiotensin ii , carbachol , ventricle , spontaneously hypertensive rat , chemistry , long term potentiation , pressor response , renin–angiotensin system , thirst , blood pressure , heart rate , receptor
SUMMARY 1. The effects of type‐C natriuretic polypeptides (CNP) on the central dipsogenic and pressor responses to angiotensin II (AngII) were studied by the administration of agents into the lateral cerebral ventricle under conscious and unrestrained conditions in normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. The fluid intake induced by AngII (25 ng) and water deprivation were potentiated after pretreatment with CNP in SHR but not in WKY rats. However, carbachol‐induced water intake was not altered by pretreatment with CNP (2.5 μg) in either WKY rats or SHR. 3. In contrast, CNP did not influence the pressor responses to AngII in either WKY rats o. SHR.