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PSYCHOMOTOR PERFORMANCE DURING INITIAL STAGE OF EXPOSURE TO HALOTHANE, ENFLURANE, ISOFLURANE AND SEVOFLURANE IN MICE
Author(s) -
Komatsu Hisao,
Nogaya Junko,
Kuratani Norihumi,
Ueki Masaaki,
Yokono Satoshi,
Ogli Kenji
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb02116.x
Subject(s) - enflurane , halothane , isoflurane , sevoflurane , inhalation , anesthesia , medicine , psychomotor learning , chemistry , cognition , psychiatry
SUMMARY 1. The dose‐response relationship during the pre‐anaesthetic and pre‐equilibrium state of four inhalation anaesthetics (halothane, enflurane, isoflurane and sevoflurane) on fixed‐ratio schedule‐controlled behaviour was studied in mice. 2. Animals exposed to halothane, enflurane and isoflurane showed a biphasic pattern (i.e. a significant incremental increase in psychomotor responses at low inspired concentrations (0.1‐0.4%) and decrements at greater concentrations) in a dose‐dependent manner. Mean peak responses (per cent of control) were 132.3 (P<0.01 vs control), 124.0 (P<0.05) and 116.7% (P<0.05) at 0.1% halothane, 0.3% enflurane and 0.2% isoflurane, respectively. 3. Sevoflurane did not increase schedule‐controlled behavioural responses at any concentration. 4. The effect of subanaesthetic concentrations of inhalation anaesthetics on psychomotor performance can be evaluated as changes in the response rate in schedule‐controlled behaviour.