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INTRARENAL LOCALIZATION OF NITRIC OXIDE SYNTHASE ISOFORMS AND SOLUBLE GUANYLYL CYCLASE
Author(s) -
Star Robert A.
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb02100.x
Subject(s) - soluble guanylyl cyclase , gene isoform , guanylate cyclase , nitric oxide , nitric oxide synthase , gucy2d , chemistry , guanylate cyclase 2c , biochemistry , cyclase , kidney , biology , endocrinology , enzyme , gene , organic chemistry
SUMMARY 1. Nitric oxide (NO) plays an important role in the regulation of renal function. To date, five isoforms of NO synthase (NOS) and four subunits of soluble guanylyl cyclase have been cloned. The kidney contains four isoforms of NOS and all sub‐units of soluble guanylyl cyclase. 2. This review focuses on the intrarenal location of the isoforms of NOS and the subunits of soluble guanylyl cyclase.