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BLOOD PRESSURE REGULATION IN BARORECEPTOR‐DENERVATED RATS
Author(s) -
Sved Alan F.,
Schreihofer Ann M.,
Jr Curtis K Kost
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb01787.x
Subject(s) - baroreceptor , denervation , blood pressure , medicine , mean arterial pressure , anesthesia , cardiology , heart rate
Key words 1. Arterial baroreceptor denervation produces acute hypertension, but chronically denervated animals have an average arterial pressure that is similar to that of baroreceptor intact animals. 2. Although cardiopulmonary baroreceptors and renal compensations have been suggested to mediate the restoration of a normal average arterial pressure in sino‐aortic denervated rats, such mechanisms are inconsistent with the available data. 3. At present the processes involved in the restoration and long‐term maintenance of a normal average arterial pressure in chronic baroreceptor denervated animals are not known. An understanding of the regulation of arterial pressure that occurs in the absence of arterial baroreceptor reflexes may provide important new insights into the mechanisms underlying the long‐term regulation of arterial pressure.