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ASSOCIATION ANALYSIS OF SIX CANDIDATE GENES IN A SAMPLE OF AUSTRALIAN HYPERTENSIVE PATIENTS
Author(s) -
Huggard PR,
Summers KM,
West J.,
West MJ
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb01224.x
Subject(s) - extracellular matrix , blood pressure , gene , genetic association , vasoactive , medicine , candidate gene , endocrinology , biology , genetics , genotype , single nucleotide polymorphism
SUMMARY 1. Essential hypertension is characterized by increased vascular resistance due to narrowing of the small arterioles. This may be influenced by vasoactive substances, cell growth and vascular remodelling. 2. A sample of Australian hypertensive and normotensive subjects was investigated for association with genetic markers which are candidates for a role in blood pressure (BP) regulation due to potential effects on vascular diameter. 3. The six markers used were for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix. 4. No significant association of any of the markers used was found with BP status in this sample of patients.