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GENETIC FACTORS ASSOCIATED WITH ALTERED SODIUM TRANSPORT IN HUMAN HYPERTENSION: A TWIN STUDY
Author(s) -
Nowson Caryl A.,
McMurchie Edward J.,
Burnard Sharon L.,
Head Richard J.,
Boehm Joanna,
Hoang Hoa N.,
Hopper John L.,
Wark John D.
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb01214.x
Subject(s) - blood pressure , monozygotic twin , dizygotic twins , twin study , endocrinology , body mass index , dizygotic twin , sodium , medicine , antiporter , chemistry , biology , genetics , heritability , obstetrics , organic chemistry
SUMMARY 1. Na + /H + antiporter/exchange activity (NHE) in human cheek epithelial cells was assessed in 288 female twins and siblings. The genetic contribution of factors to NHE activity was assessed in 128 matched twin pairs (76 monozygotic (MZ); 52 dizygotic (DZ)). 2. There was a small reduction in NHE with age and body mass index. The significant correlations (± their standard error (SE)) within MZ and DZ pairs of twins were 0.54 ± 0.08 and 0.26 ± 0.13, respectively, implying that genetic factors accounted for 54% of the variance in age‐adjusted NHE. There was no cross‐sectional relationship between NHE and measures of blood pressure. Based on within‐pair differences, however, there was a weak negative association ( r = 0.22; P < 0.05) between mean arterial pressure and NHE. 3. It remains to be determined whether NHE in cheek cells is associated with blood pressure tracking over time in young females.