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EFFECT OF EXERCISE ON PLASMA ADRENOMEDULLIN AND NATRIURETIC PEPTIDE LEVELS IN MYOCARDIAL INFARCTION
Author(s) -
Morimoto Atsushi,
Nishikimi Toshio,
Takaki Hiroshi,
Okano Yoshiaki,
Matsuoka Hiroaki,
Takishita Shuichi,
Kitamura Kazuo,
Miyata Atsuro,
Kangawa Kenji,
Matsuo Hisayuki
Publication year - 1997
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1997.tb01194.x
Subject(s) - medicine , pulmonary wedge pressure , adrenomedullin , cardiology , preload , atrial natriuretic peptide , brain natriuretic peptide , natriuretic peptide , heart failure , myocardial infarction , hemodynamics , central venous pressure , blood pressure , endocrinology , heart rate , receptor
SUMMARY 1. We investigated the effect of exercise on plasma adreno‐medullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. The exercise protocol consisted of two fixed work loads (40 and 80 W) for 4 min each and venous blood samples were taken at rest, during each exercise stage and after exercise while monitoring the mean arterial pressure (MAP) and heart rate (HR). In MI, pulmonary arterial pressure (PAP), pulmonary capillary wedge pressure (PCWP), left ventricular end‐diastolic pressure (LVEDP) and cardiac output (CO) were measured throughout exercise. 3. Adrenomedullin levels did not significantly increase with exercise. Adrenomedullin levels correlated with PAP and PCWP at rest ( P < 0.05). Atrial natriuretic peptide levels correlated with PAP, PCWP and LVEDP throughout exercise ( P < 0.05) but, on multiple regression analysis, PCWP correlated only with ANP ( P < 0.01). Brain natriuretic peptide levels correlated with LVEDP throughout exercise ( P < 0.01) and its increment correlated closely with basal BNP levels at rest ( P < 0.01). 4. These results suggest that adrenomedullin does not respond to the acute haemodynamic changes of exercise, whereas ANP responds to it and PCWP is the major stimulus factor. Brain natriuretic peptide responds to exercise in proportion to the basal synthesis of BNP in patients with left ventricular dysfunction and LVEDP may play a role in increasing BNP during exercise.