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SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ENDOTHELIN IS A KEY MODULATOR OF PROGRESSIVE RENAL INJURY: EXPERIMENTAL DATA AND NOVEL THERAPEUTIC STRATEGIES
Author(s) -
Bruzzi Isabella,
Benigni Ariela
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb02836.x
Subject(s) - endothelin receptor , receptor , pharmacology , medicine , endothelin 1 , renal function , function (biology) , neuroscience , biology , microbiology and biotechnology
SUMMARY 1. Glomerulosclerosis and tubulointerstitial damage are common histological abnormalities of many renal diseases that progress to end‐stage renal failure. 2. In some models of renal damage, glomerulosclerosis seems to be associated with increased glomerular capillary pressure. 3. Due to the positive correlation of glomerulosclerosis and proteinuria in both experimental models and in humans, abnormal permeability to macromolecules has also been considered a possible determinant of glomerulosclerosis. 4. Abnormally filtered macromolecules have an intrinsic toxicity to the kidney due to protein over‐reabsorption, possibly leading to tubulointerstitial damage. 5. Endothelin‐1 (ET‐1) is a vasoconstrictor peptide that induces mitogenesis and the accumulation of matrix proteins by mesangial cells. 6. Evidence is available that ET‐1 plays a role in progressive renal disease in different experimental models, including renal mass reduction, lupus nephritis, streptozotocin‐induced diabetes and puromycin‐induced nephrosis.