Premium
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ENDOTHELIN RECEPTORS IN NORMAL AND DISEASED KIDNEYS
Author(s) -
Nambi Ponnal
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb02832.x
Subject(s) - endothelin receptor , receptor , endocrinology , medicine , endothelin 1 , function (biology) , renal function , biology , microbiology and biotechnology
SUMMARY 1. Endothelin‐1 (ET‐1), the most potent vasoconstrictor yet identified, mediates a multitude of responses in various tissues including the kidney. The biological responses of ET‐1 are mediated by specific cell surface receptors classified as ET A and ET B . Species differences are observed in the distribution as well as function of these ET receptors. 2. Involvement of ET has been demonstrated in a number of renal diseases, including ischaemia‐induced acute renal failure, chronic renal failure, radiocontrast and cyclosporin‐induced nephrotoxicity. ET antibodies as well as ET receptor antagonists have been shown to be beneficial in these disease models.