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CALCITONIN GENE‐RELATED PEPTIDE ANTAGONIZES THE PROTECTIVE EFFECT OF ADRENOMEDULLIN ON HISTAMINE‐INDUCED BRONCHCTION
Author(s) -
Kanazawa Hiroshi,
Kawaguchi Takashi,
Kamoi Hiroshi,
Fujii Tatsuo,
Kudoh Shinzoh,
Hirata Kazuto,
Kurihara Naotsugu,
Yoshikawa Junichi
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb02763.x
Subject(s) - adrenomedullin , calcitonin gene related peptide , calcitonin , histamine , endocrinology , peptide , medicine , chemistry , pharmacology , neuropeptide , biochemistry , receptor
SUMMARY 1. In the present study the possible relationship between adrenomedullin (AM) and calcitonin gene‐related peptide (CGRP) in the regulation of airway functions in anaesthetized guinea‐pigs was examined in vivo . 2. We found that AM significantly inhibited histamine‐induced bronchoconstriction in a dose‐dependent manner. CGRP or the CGRP receptor antagonist (CGRP [8–37]) alone did not affect pulmonary resistance and pretreatment with CGRP or CGRP [8–37] did not significantly affect histamine‐induced bronchoconstriction. However, AM‐induced broncho‐protection was significantly inhibited by pretreatment with CGRP or CGRP [8–37] in a dose‐dependent manner. 3. It is therefore possible that CGRP may be competitive, at least in part, with binding sites of AM in the guinea‐pig airway. Exogenous AM may be useful for the management of bronchial asthma, not only as a potent bronchodilator, but also as a functional antagonist of CGRP.