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EFFECTS OF HISTAMINE AND 5‐HYDROXYTRYPTAMINE ON THE GROWTH RATE OF XENOGRAFTED HUMAN BRONCHOGENIC CARCINOMAS
Author(s) -
Sheehan Peter FJ,
Baker Timothy,
Tutton Peter JM,
Barkla David H
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb02762.x
Subject(s) - cimetidine , ketanserin , histamine , quipazine , agonist , ranitidine , pharmacology , medicine , endocrinology , chemistry , histamine h2 receptor , 5 ht receptor , receptor antagonist , receptor , antagonist , serotonin
SUMMARY 1. The influence of histamine and 5‐hydroxytryptamine (5‐HT) antagonists and agonists on the volume doubling times (Td) of human bronchogenic carcinomas propagated as s. c. xenografts in immunosuppressed mice was examined. 2. The H 2 ‐receptor antagonists, cimetidine and ranitidine, increased Td. 3. Treatment with the H 2 ‐receptor agonist, 4‐methyl histamine, had no effect on Td. 4. Co‐administration of 4‐methyl histamine and cimetidine abolished the effects of cimetidine. 5. The 5‐HT 2 ‐receptor antagonists, cinanserin and ketanserin, both increased Td. 6. Treatment with the 5‐HT 1/2 ‐receptor agonist quipazine (0.1 mg/kg, reflecting 5‐HT 2 agonist activity) decreased Td, while a higher dose (10.0mg/kg) had no effect. 7. The 5‐HT 1/2 ‐receptor antagonist, methiothepin, decreased Td. 8. The 5‐HT uptake inhibitor, fluoxetine, increased Td in one tumour line but not in another, while the 5‐HT releaser/depletor, fenfluramine, increased Td. 9. Histamine may stimulate tumour growth through the histamine H 2 ‐receptor, while the dominant effect of 5‐HT is 5‐HT 1 ‐receptor inhibition. 10. Tumour growth in some bronchogenic carcinomas may involve 5‐HT uptake mechanisms.