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SUPPRESSIVE EFFECTS OF A HERBAL FORMULA, TBL‐1, ON TYPE II COLLAGEN‐INDUCED ARTHRITIS IN DBA/1J MICE
Author(s) -
Li SongHua,
Kobayashi Yuta,
Yamauchi Yasutaka,
Gonda Tatsuo,
Tsunematsu Tokugoro
Publication year - 1996
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1996.tb02602.x
Subject(s) - medicine , arthritis , type ii collagen , immune system , collagen induced arthritis , immunization , immunology , pharmacology
SUMMARY 1. The effects of a formula of traditional Chinese medicine, TBL‐1, on collagen‐induced arthritis (CIA) were investigated in DBA/1J mice. 2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL‐1 or indomethacin was administered orally for 13 weeks. 3. Clinical scores of CIA were decreased by both TBL‐1 and indomethacin intervention compared with the control CII‐immunized group. 4. Radiographic scores of phalangeal destruction were markedly improved by TBL‐1 intervention ( P <0.001), but indomethacin failed. 5. The suppressive effects of TBL‐1, but not indomethacin, were manifested in reduced serum anti‐CII antibody titres ( P <0.001). 6. These findings suggest that TBL‐1 may play a role in regulating some immune responses in the present arthritis model.